Erythropoietin prevents lymphoid apoptosis but has no effect on survival in experimental sepsis

PTX3 in serum induces renal mesangial cell proliferation but has no effect on apoptosis

The present study aimed to investigate the effect of pentraxin 3 (PTX3) on the regulation of proliferation and apoptosis in human glomerular mesangial cells (HMCs). Small interfering (si)RNA was designed and synthesized to inhibit the expression of endogenous PTX3, and the effects on the proliferation and apoptosis of HMCs were detected by flow cytometry and an MTT assay. Western blot analysis ...

Propolis has no effect on tendon healing: an experimental study

Tendon healing remains a slow process due to less blood supply compared to many other tissues. In previous studies, propolis was shown to modify collagen types I and III accumulation at wound healing site and positively affected wound healing however, no study has shown the effects of propolis on tendon healing. We aimed to investigate the effect of propolis on tendon healing. Twenty eight male...

Methotrexate has no antifibrotic effect in bleomycin-induced experimental scleroderma.

Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.

The cytokine erythropoietin (EPO) possesses potent neuroprotective activity against a variety of potential brain injuries, including transient ischemia and reperfusion. It is currently unknown whether EPO will also ameliorate spinal cord injury. Immunocytochemistry performed using human spinal cord sections showed abundant EPO receptor immunoreactivity of capillaries, especially in white matter...

Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin.

The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice) develop severe anemia that has been attributed to hemolysis and is accompanie...